Abstract: Nuclear power is the clean energy energetically by the state. Nuclear power generation equipment is an important part of nuclear power plant systems engineering, whose quality would have a crucial impact on the safe operation of nuclear power plant. Therefore, the research and manufacturing corporation should pay more attention to the project management of nuclear power generation equipment supply project, coordinate the relationship between the relevant parties, and then improve the equipment manufacturing quality and output efficiency, to ensure the smooth implementation of nuclear power plant construction. This paper mainly studies how to improve the project management work of nuclear power generation equipment supply project.