Abstract: Based on the needs of improving production management quality and efficiency in the development process of nuclear power equipment, and summarizing the characteristics of small batch production, long cycle, strict supervision, multiple collaborative elements, and strict quality requirements in nuclear power equipment manufacturing, this paper analyzes the manufacturing digital collaboration mode of the entire process, organization, and element collaboration of nuclear power equipment manufacturing. A collaborative mode for the entire process of nuclear power equipment manufacturing based on product digital models is proposed. Through the construction of digital scenarios, seamless integration and efficient collaboration between various links are promoted, and the internal and external information barriers of key business nodes such as manufacturing process design, planning integration, production preparation and execution, and quality management are broken down. An integrated platform is constructed and successfully applied in actual production management, achieving the unity and collaboration of data, process, and management.